Approximately 60% of patients will experience symptoms because of these high levels of hormones in the blood. ![]() Some adrenal cancers, and even some benign adenomas, are functional and secrete excessive amounts of hormones. They secrete hormones and are called functional tumors, or they do not and are called non-functional tumors. Some patients describe feeling full with no appetite because of pressure on the stomach and other abdominal organs. Symptoms of chronic adrenal insufficiency include low blood pressure, fatigue, weight loss, anorexia, nausea, vomiting, abdominal pain, salt craving and low. In adrenocortical cancer, these symptoms usually are due to pressure caused by the tumor as it compresses organs, nerves and other structures around the adrenal gland. Unfortunately, this type of pain is common and does not directly suggest a disease of the adrenal cortex. The most common symptom reported by patients with adrenocortical cancer is pain in the back or side (called the flank). ![]() Fewer than 30% of adrenocortical cancers are confined to the adrenal gland at the time of diagnosis. Most adrenocortical cancers are found after they have been growing for years.
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